Soluble in Ethyl Acetate and DMSO
Parthenolide inhibits activation of MAP kinase. Also has anti-inflammatory and anti-secretory properties.
Parthenolide Inhibits TNF/IL-1 or TNFInduced Production of IL-81. Parthenolide Inhibits I B Kinase, NF- B Activation, and Inflammatory Response in Cystic Fibrosis Cells and Mice.
NF-B inhibitor parthenolide and the COX-2 inhibitor NS398 each inhibited hepatocellular carcinoma growth in a concentration-dependent manner. In addition, the combination of parthenolide and NS398 reduced the concentration of NS398 required to inhibit hepatocellular carcinoma growth. Parthenolide Cooperates with NS398 to Inhibit Growth of Human Hepatocellular Carcinoma Cells through Effects on Apoptosis and G-G Cell Cycle Arrest. Nuclear Factor- B Inhibition by Parthenolide Potentiates the Efficacy of Taxol in NonSmall Cell Lung Cancer.The NF-B inhibitor, parthenolide, may enhance chemosensitivity to paclitaxel in the treatment of patients with gastric cancer. Enhances Response to Chemotherapy in Gastric Cancer.
Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions.
Additional Reading: Pathology Research Using Mitophagy Modulators
Research or further manufacturing use only, not for food or drug use.