1226056-71-8
311.36 Da
C15H13N5OS
DMSO at ≥30 mg/mL
-20°C
Description
Thiazovivin is a Rho-associated kinase inhibitor which acts on the ROCK signaling pathway known to mediate several key cellular functions, including gene expression. Thiazovivin, sometimes abbreviated to TZV, is cell-permeable and has been put to wide use in studies of cell differentiation and transition because of its inhibitory effect on the ROCK pathway.
Applications
Research has shown that this inhibitor supports the survival and renewal of stem cells in both human and animal subjects. At least one human study has demonstrated thiazovivin's ability to inhibit the endothelial-to-mesenchymal and epithelial-to-mesenchymal transitions which are associated with corneal disease.
TZV has also been used in experiments relating to chemical reprogramming of cells. In one prominent example, thiazovivin was applied to porcine embryonic fibroblasts in conjunction with the TGF-beta growth factor SB431542, causing the PEFs to be reprogrammed as apidocytes.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
