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  • SKU: C-2216-INQUIRE
  • Pack Size: INQUIRE

289499-45-2

558.86

C24H25ClFN5O3 2HCl

DMSO (100 mg/ml)

-20°C


Canertinib is an irreversible tyrosine kinase inhibitor.It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules. Canertinib alkylates a cysteine residue specific to ErbB receptors. The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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