99533-80-9
467.5
C27H21N3O5
May be dissolved in DMSO (100 mg/mL)
-20°C
Description
K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. A general protein kinase inhibitor. CaM, PKC , PKG , myosin light chain kinase .Attached is a published reference from researchers who have used our K-252a product.A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity.
Applications
Pharmacology: Potent pan-specific protein kinase inhibitor: PKA (Ki = 18 nM), PKC (Ki = 25 nM) PKG (Ki = 20 nM)1 . Inhibits CaMK (Ki = 1.8 nM)2 and phosphorylase kinase (IC50 = 1.7 nM)3 as well as other kinases4 . Induces apoptosis . Cell permeable.
Fermentation product from Nocardiopsis sp.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
