C16H18N2OS • HBr
Soluble in DMSO, DMF, Methanol
Pifithrin-α Hydrobromide is a chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. It reversibly blocks p53 dependent transcriptional activation and apoptosis.
• p53 Mediates Nontranscriptional Cell Death in Dopaminergic Cells in Response to Proteasome Inhibition
• p53 Down-Regulates Phosphatase and Tensin Homologue Deleted on Chromosome 10 Protein Stability Partially through Caspase-Mediated Degradation in Cells with Proteasome Dysfunction
• Histone Deacetylase Inhibitor-Mediated Radiosensitization of Human Cancer Cells: Class Differences and the Potential Influence of p53
• Early Single Cell Bifurcation of Pro- and Antiapoptotic States during Oxidative Stress
Not for human therapeutic use or for medicinal purposes. For research applications only.
Research or further manufacturing use only, not for food or drug use.