9087-70-1
6511.44
C284H432N84O79S7
Clear, colorless solution. 1% freely soluble in water.
+4°C
Description
Aprotinin is a natural serine protease inhibitor from bovine lung tissue. It inhibits trypsin, chymotrypsin, Factor XII, plasmin and kallikrein which are related to fibrinolysis. Some proteases like Factor Xa, thrombin and pepsin are not affected by aprotinin. It is heat- and acid-stable, however it dissociates at pH >10 or <3 from most aprotinin-proteases. Effective concentration is equimolar with protease. It is also used to preserve platelet number and organs for transplantation and function for transfusion.
Applications
• Protein purification
• Used to preserve biological fluids, cells, and tissues from proteolytic damage
References
• "Aprotinin: A Review of its Pharmacology and Therapeutic Efficacy in Reducing Blood Loss Associated with Cardiac Surgery"
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
