Camostat mesilate, 10 MG

Home Inhibitors Protein Inhibitors Protease Inhibitors Camostat mesilate, 10 MG

Price$ 42.35

Description

CAS Number: 59721-29-8

Molecular Weight: 494.5 Da

Chemical Formula: C₂₀H₂₂N₄O₅ • CH₃SO₃H

Solubility: May be dissolved in DMSO (50 mg/mL) or Water (50 mg/mL)

Storage Temperature: -20°C

Description

A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis¹ . Reduces weight gain and improves metabolism in obese rodent models² . In clinical use (in Japan) for pancreatitis³ . Inhibits influenza virus replication in human tracheal epithelial cells⁴ . Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming⁵ .

Shown to be effective against coronavirus.

References

• Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity

• Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice

• The Serine Protease Inhibitor Camostat Mesilate Attenuates the Progression of Chronic Kidney Disease through its Antioxidant Effects

• The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells

• SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Not for human therapeutic use or for medicinal purposes. For research applications only.

Shipping Weight: 0.1 lbs

Research or further manufacturing use only, not for food or drug use.