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Celastrol, 5 MG

Price$ 64.80
  • SKU: C-2262-5MG
  • Pack Size: 5 MG
Quantity
-
+

34157-83-0

450.61

C29H38O4

Methanol: Clear red solution at 10 mg/mL

-20°C


Description

Celastrol (also known as Tripterin) is a cell-permeable proteasome inhibitor. Acts as an antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC= 40 nM for IL-1 and IL-1, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF). Suppresses nitric oxide (NO) production (IC= 230 nM) and LPS-induced NF-B activation (IC= 270 nM).Inhibits chymotrypsin-like activity of 20S proteasome (IC= 2.5 M) and lipid peroxidation induced by ADP and Fe in rat liver mitochondria (IC= 7 M).

Isolated from Tripterygium wilfordii.

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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