49843-98-3
248.71
C13H13ClN2O
Soluble in DMSO (20 mg/ml)
+4°C
A potent SIRT1 inhibitor (IC= 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100M. Enhances p53 acetylation in response to DNA damaging agents.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
