DMSO (~25 mg/ml)
Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC< 10M). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-B activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
Research or further manufacturing use only, not for food or drug use.