Soluble in DMSO
A membrane permeant indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-R, 4.92 M for p60c-src, and 13.3 M for FGF-R1]. The inhibition is suggested to be competitive with respect to ATP. Also inhibits VEGF-induced (IC = 100 nM) and PDGF-induced (IC = 2.01 M)cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC 100 M).
Research or further manufacturing use only, not for food or drug use.