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VEGFR2 Kinase Inhibitor II

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  • SKU: V-1080
  • Pack Size: 1 g
VEGFR2 Kinase Inhibitor II

288144-20-7

343.2

C17H15BrN2O

Soluble in DMSO

-20°C


Synonym: (Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one

A membrane permeant indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-R, 4.92 M for p60c-src, and 13.3 M for FGF-R1]. The inhibition is suggested to be competitive with respect to ATP. Also inhibits VEGF-induced (IC = 100 nM) and PDGF-induced (IC = 2.01 M)cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC 100 M).

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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