Prostaglandin E2

SKU
P-2479
  • CAS:363-24-6
  • Formula:C20H32O5
  • MW:352.5<
  • Appearance:A crystalline solid
  • Purity:≥99%
Product Name Qty
Prostaglandin E2
10 mg
$118.46
Prostaglandin E2
50 mg
$518.28

PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, andEP5. Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue. The effect of PGE2 in endometrial angiogenesis, uterine receptivity, and decidualization is mediated by cAMP-dependent mechanisms in rats, rabbits, and humans.



 

More Information
Alternate Name/Synonyms
Dinoprostone, PGE2
SKU
P-2479
CAS #
363-24-6
Chemical Name
9-oxo-11α, 15S-dihydroxy-prosta-5Z, 13E-dien-1-oic acid
Chemical Formula
C20H32O5
Molecular Weight
352.5<
Appearance
A crystalline solid
Purity
≥99%
Solubility
Soluble in acetone, ethanol (50mg/ml), DMSO (50 mg/ml), water(Partly miscible), DMF (100mg/ml), PBS,
Melting Point
66.1-67.8 °C
Storage Temp
-20°C
Citations
IMMUNOLOGY: Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines Rajesh Narasimamurthy, Megumi Hatori, Surendra K. Nayak, Fei Liu, Satchidananda Panda, and Inder M. Verma PNAS, Jul 2012; 109: 12662 - 12667.
Citations_Hyperlink
http://www.pnas.org/cgi/reprint/109/31/12662
Certificate of Analysis 1
Certificate of Analysis 2
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