Proteasome Substrate II (Fluorogenic)

SKU
P-1161
  • Formula:C35H44N4O9
  • MW:664.8
  • Appearance:Off white, Lyophilized
  • Purity:95%

Starting at $33.50

Product Name Qty
Proteasome Substrate II (Fluorogenic)
1 mg
$33.50
Proteasome Substrate II (Fluorogenic)
5 mg
$159.70
Fluorogenic proteasome substrate. Good for measuring the peptidylglutamyl peptide-hydrolyzing activity of the 20S proteasome.
More Information
Alternate Name/Synonyms
Z-LLE-AMC; Z-Leu-Leu-Glu-AMC
SKU
P-1161
Chemical Name
Z-Leu-Leu-Glu-AMC
Chemical Formula
C35H44N4O9
Molecular Weight
664.8
Appearance
Off white, Lyophilized
Purity
95%
Solubility
DMSO
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.
MDL NUMBER
MFCD01074989
CHEMACX
X1206432-1
INCHI
InChI=1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1
SMILES
Cc1cc(=O)oc2c1ccc(c2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc3ccccc3
Peptide sequence
Z-LEU-LEU-GLU-AMC
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Citations
LYMPHOID NEOPLASIA: Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells Claudia P. Miller, Sharmistha Rudra, Michael J. Keating, William G. Wierda, Michael Palladino, and Joya Chandra Blood, Apr 2009; 113: 4289 - 4299.
Citations_Hyperlink
http://bloodjournal.hematologylibrary.org/cgi/reprint/113/18/4289
Promo text for AGS discount
N/A
UN #'S Not Applicable
Packing Group Not Applicable
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