Proteasome Substrate III (Fluorogenic)

SKU
P-1163
  • Formula:C40H53N5O10
  • MW:762.9
  • Appearance:White to off-white lyophilized Powder
  • Purity:98% (HPLC)
Product Name Qty
Proteasome Substrate III (Fluorogenic)
5 mg
$269.13
Proteasome Substrate III (Fluorogenic)
1 mg
$27.92
Fluorogenic proteasome substrate. Also acts as a substrate for many other proteinases. Good for measuring the chymotrypsin-like peptidase activity of the 20S proteasome
More Information
Alternate Name/Synonyms
Suc-Leu-Leu-Val-Tyr-AMC; Suc-LLVY-AMC; Calpain Substrate (Fluorogenic)
SKU
P-1163
Chemical Name
Suc-Leu-Leu-Val-Tyr-AMC
Chemical Formula
C40H53N5O10
Molecular Weight
762.9
Appearance
White to off-white lyophilized Powder
Purity
98% (HPLC)
Solubility
DMSO (30 mg/ml) or Ethanol (2 mg/ml)
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Fluorogenic substrate for the measurement of the chymotrypsin-like peptidase activity of the 20S proteasome
MDL NUMBER
MFCD00080248
CHEMACX
X2814236-7
INCHI
InChI=1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)/t29-,30-,31-,36-/m0/s1
SMILES
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CCC(=O)O
Peptide sequence
SUC-LEU-LEU-VAL-TYR-AMC
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store tightly sealed. Protect from Light
Citations
LYMPHOID NEOPLASIA: Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells Claudia P. Miller, Sharmistha Rudra, Michael J. Keating, William G. Wierda, Michael Palladino, and Joya Chandra Blood, Apr 2009; 113: 4289 - 4299.
Citations_Hyperlink
http://bloodjournal.hematologylibrary.org/cgi/reprint/113/18/4289
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Promo text for AGS discount
N/A
Handling Store tightly sealed. Protect from Light
UN #'S Not Applicable
Packing Group Not Applicable
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