Purmorphamine

SKU
P-1633
  • CAS:483367-10-8
  • Formula:C31H32N6O2
  • MW:520.6
  • Appearance:Beige Solid Packaged under inert gas
  • Purity:98% by HPLC
Product Name Qty
Purmorphamine
1 mg
$45.56
Purmorphamine
5 mg
$165.17

A cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC = 1 M) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.

More Information
Alternate Name/Synonyms
Shh Signaling Agonist
SKU
P-1633
CAS #
483367-10-8
Chemical Name
2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Chemical Formula
C31H32N6O2
Molecular Weight
520.6
Appearance
Beige Solid Packaged under inert gas
Purity
98% by HPLC
Solubility
DMSO (200 mg/ml)
Storage Temp
+4°C
THERAPEUTIC AREA
Musculoskeletal Disorders
USE
An activator of the hedgehog (Hh) signaling pathway induce osteogenesis in bone tissue
MDL NUMBER
MFCD09037557
CHEMACX
X1600485-6
INCHI
InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
SMILES
c1ccc2c(c1)cccc2Oc3nc(c4c(n3)n(cn4)C5CCCCC5)Nc6ccc(cc6)N7CCOCC7
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from Light Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Handling Protect from Light Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
UN #'S Not Applicable
Packing Group Not Applicable
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