Purvalanol A

SKU
P-2481
  • CAS:212844-53-6
  • Formula:C19H25ClN6O
  • MW:388.9
  • Appearance:Pale-green powder
  • Purity:>98% (HPLC)
Product Name Qty
Purvalanol A
5 mg
$26.74
Purvalanol A
25 mg
$106.95

Pharmacology:  Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively. Reversibly arrests synchronized cells in G1 and G2 phase. Induces ER stress-mediated apoptosis and autophagy in colon cancer cells. Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis. Cell permeable.

More Information
Alternate Name/Synonyms
NG-60
SKU
P-2481
CAS #
212844-53-6
Chemical Name
(2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Chemical Formula
C19H25ClN6O
Molecular Weight
388.9
Appearance
Pale-green powder
Purity
>98% (HPLC)
Solubility
May be dissolved in DMSO (35 mg/ml)
Storage Temp
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.
Hazard Image
Yes
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