PYR-41

SKU
P-2410
  • CAS:418805-02-4
  • Formula:C17H13N3O7
  • MW:371.3
  • Appearance:Brown Solid
  • Purity:98% by TLC
Product Name Qty
PYR-41
5 mg
$96.82
PYR-41
25 mg
$381.58
Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC< 10M). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-B activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
More Information
Alternate Name/Synonyms
4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
SKU
P-2410
CAS #
418805-02-4
Chemical Name
4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
Chemical Formula
C17H13N3O7
Molecular Weight
371.3
Appearance
Brown Solid
Purity
98% by TLC
Solubility
DMSO (~25 mg/ml)
Melting Point
258.53 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
PYR 41 is an irreversible and cell-permeable UBE1 (ubiquitin-activating enzyme E1) inhibitor as therapeutics in cancer
MDL NUMBER
MFCD01469983
CHEMACX
X3304879-0
INCHI
InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
SMILES
CCOC(=O)c1ccc(cc1)N2C(=O)/C(=C\c3ccc(o3)[N+](=O)[O-])/C(=O)N2
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and air
Handling Protect from light and air
UN #'S Not Applicable
Packing Group Not Applicable
To Top