Pyridoxal-5-Phosphate

SKU
P-2907
  • CAS:41468-25-1
  • Formula:C8H10NO6P • H2O
  • MW:265.1 Da
  • Appearance:Off-white to yellow solid
  • Purity:≥ 98 %

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Product Name Qty
Pyridoxal-5-Phosphate
5 g
$69.99
Pyridoxal-5-Phosphate
100 g
$524.99
Pyridoxal-5-Phosphate
25 g
$199.99

Description

Pyridoxal-5-phosphate, sometimes abbreviated as P5P, is the active form of vitamin B6. As such, P5P plays a wide variety of essential physiological roles, including acting as a cofactor of various neurotransmitters, regulating hormone and gene expression and facilitating the synthesis of certain amino acids.

Applications

Like other vitamin forms, P5P has been the subject of intensive biomedical and pharmacological research over many years. Studies have shown that increased plasma levels of P5P correlate with a lower risk of breast cancer in postmenopausal women, as well as with lower levels of recognized inflammation markers in the general population. The P5P form of vitamin B6 has also been shown to exert cardioprotective effects in patients suffering from ischemic heart disease. While the mechanism by which P5P protects the cardiovascular system has not yet been definitively established, there is evidence to suggest that the effect is a result of the vitamin's ability to prevent overload of Ca2+ ions.

 

More Information
Alternate Name/Synonyms
Pyridoxal 5-phosphate monohydrate; 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde; Codecarboxylase; PLP; Pyridoxal 5-phosphate
SKU
P-2907
CAS #
41468-25-1
Chemical Name
(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate;hydrate
Chemical Formula
C8H10NO6P • H2O
Molecular Weight
265.1 Da
Appearance
Off-white to yellow solid
Purity
≥ 98 %
Melting Point
140 – 143°C
Storage Temp
4ºC
THERAPEUTIC AREA
Neurological Disorders
USE
Pyridoxal 5′-phosphate (PLP) is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. PLP is used in the studies of PLP-dependent enzyme active sites. It is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.
Handling
Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.
Certificate of Analysis 1
Handling Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.
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