R-(-)-Rolipram

SKU
R-1013
  • CAS:85416-75-7
  • Formula:C16H21NO3
  • MW:275.35
  • Appearance:Solid
  • Purity:>98%
Product Name Qty
R-(-)-Rolipram
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$0.00

More active enantiomer of (R,S)-Rolipram: 2-10-fold more potent that the (S)-(+)-enantiomer. Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It was previously used as an antideppresant but was discontinued because of its serious side effects. Rolipram has shown to boost the levels of NMNAT2 (Nicotinamide mononeucleotide adenylyl transferase 2), an enzyme that blocks the processes associated with dementia - a form of Alzheimers. In other studies it has shown to breakdown misfolded tau proteins.

*Also See R1012 (R,S) Rolipram or R-1203 (S) Rolipram.

More Information
SKU
R-1013
CAS #
85416-75-7
Chemical Name
(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Chemical Formula
C16H21NO3
Molecular Weight
275.35
Appearance
Solid
Purity
>98%
Solubility
Soluble in DMSO (to 100mM)
Melting Point
132.2 °C
Storage Temp
Store at +4°C under desiccating conditions.
USE
Used in Neurodegenrative Disease research as a PDE4 inhibitor.
MDL NUMBER
MFCD03093860
CHEMACX
X1461532-8
INCHI
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
SMILES
COc1ccc(cc1OC2CCCC2)[C@H]3CC(=O)NC3
Handling
Protect from Moisture
HandlingProtect from Moisture
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