R-(R)-Roscovitine, selective CDK Inhibitor

SKU
R-1016
  • CAS:186692-46-6
  • Formula:C19H26N6O
  • MW:354.5
  • Appearance:White Solid, powder.
  • Purity:>99%
Product Name Qty
R-(R)-Roscovitine, selective CDK Inhibitor
5 mg
$119.60
R-(R)-Roscovitine, selective CDK Inhibitor
10 mg
$216.43
R-(R)-Roscovitine, selective CDK Inhibitor
50 mg
$512.58

Potent and selective inhibitor of cyclin-dependent kinases (cdks). Selective for CDK1, CDK2, and CDK5.A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis.Dying and Necrotic Neutrophils Are Anti-Inflammatory Secondary to the Release of -Defensins.Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages.Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures.

More Information
Alternate Name/Synonyms
2-(R)-1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine,Roscovitine
SKU
R-1016
CAS #
186692-46-6
Chemical Name
2-(R)-1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
Chemical Formula
C19H26N6O
Molecular Weight
354.5
Appearance
White Solid, powder.
Purity
>99%
Solubility
Soluble in chloroform (50mg/ml), ethanol or warm DMSO @ (10mg/ml), or methanol; moderately soluble in water.
Melting Point
Not reported
Storage Temp
Keep cool and dry at -20°C. Protect from light!
THERAPEUTIC AREA
Oncological Disorders
USE
A potent and selective inhibitor of cyclin-dependent kinases. Selective for CDK1, CDK2, and CDK5
MDL NUMBER
MFCD02266401
CHEMACX
X1192610-4
INCHI
InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
SMILES
CC[C@H](CO)Nc1nc(c2c(n1)n(cn2)C(C)C)NCc3ccccc3
Handling
Store in Tightly Sealed Vial Protect from Moisture.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Store in Tightly Sealed Vial Protect from Moisture.
Citations Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine
Requirement for RORgamma in Thymocyte Survival and Lymphoid Organ Development
Rhythmic modulation of the hematopoietic niche through neutrophil clearance
Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation
Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma
5-HT causes an increase in cAMP that stimulates, rather than inhibits, oocyte maturation in marine nemertean worms
Proliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching
Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture
Link between DNA damage and centriole disengagement/reduplication in untransformed human cells
Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis
Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1
Dissecting the role of Rho-mediated signaling in contractile ring formation
Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations
CDK2 and CDK4 play important roles in promoting the proliferation of SKOV3 ovarian carcinoma cells induced by tumor-associated macrophages
A Tale of Two Projects: Basis for Centrosome Amplification after DNA Damage and Practical Assessment of Photodamage in Live-Cell Imaging: A Dissertation
Behandlung mit CDK5 Inhibitor bei der Myelin Oligo-dendrozyten Glykoprotein (MOG) induzierten experimentellen autoimmunen Encephalomyelitis (EAE)
Serum and urinary biomarker signatures for rapid preclinical in vivo assessment of CDK inhibition as a therapeutic approach for PKD
Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures
Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses
Cyclin-dependent kinase (CDK) inhibitor drugs induce apoptosis in human neutrophils through regulation of critical survival proteins
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