(R,S)-Rolipram, Inhibitor of PDE IV
SKU
R-1012
- CAS:61413-54-5
- Formula:C16H21NO3
- MW:275.4 Da
- Appearance:White solid
- Purity:≥98%
SDS
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Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It was previously used as an antideppresant but was discontinued because of its serious side effects. Rolipram has shown to boost the levels of NMNAT2 (Nicotinamide mononeucleotide adenylyl transferase 2), an enzyme that blocks the processes associated with dementia - a form of Alzheimers. In other studies it has shown to breakdown misfolded tau proteins.
More Information
Alternate Name/Synonyms
ZK-62711
SKU
R-1012
CAS #
61413-54-5
Chemical Name
4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Chemical Formula
C16H21NO3
Molecular Weight
275.4 Da
Appearance
White solid
Purity
≥98%
Solubility
Soluble in Water
Melting Point
132°C
Storage Temp
4°C, desiccated
THERAPEUTIC AREA
Neurodegenrative Diseases
USE
Rolipram is a selective, cell-permeable inhibitor of cAMP-specific PDE (phosphodiesterase) (PDE4, IC50=1 μM). This compound has been shown to inhibit PDE4 activity in human cavernosal tissue, which interrupts the signal transduction pathway of erectile response. Rolipram promotes apoptosis in HL60 cells through a cAMP-independent mechanism and has been shown to enhance neuronal survival. Rolipram is an inhibitor of PDE4A1 and PDE4B.
Merck Index
13.8332.2001
MDL NUMBER
MFCD00270906
CHEMACX
X1038250-2
INCHI
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
SMILES
COc1ccc(cc1OC2CCCC2)C3CC(=O)NC3
RTECS
UY5749237
Handling
Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.
Citations
BEHAVIORAL/SYSTEMS/COGNITIVE:
Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling
Yun-Feng Li, Yu-Fang Cheng, Ying Huang, Marco Conti, Steven P. Wilson, James M. O'Donnell, and Han-Ting Zhang
J. Neurosci., Jan 2011; 31: 172 - 183.
Citations_Hyperlink
http://www.jneurosci.org/cgi/reprint/31/1/172
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
| Handling | Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed. |
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