Rebeccamycin

SKU
R-2587
  • CAS:93908-02-2
  • Formula:C27H21Cl2N3O7
  • MW:570.4
  • Appearance:Dull yellow lyophilisate
  • Purity:>99% by HPLC
Product Name Qty
Rebeccamycin
0.5 mg
$282.29
Rebeccamycin
2.5 mg
$897.66
*Please inquire the availability for this product. Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumor activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebeccamycin have been tested in clinical trials for cancer therapy.
More Information
SKU
R-2587
CAS #
93908-02-2
Chemical Formula
C27H21Cl2N3O7
Molecular Weight
570.4
Appearance
Dull yellow lyophilisate
Purity
>99% by HPLC
Solubility
Soluble in DMSO (=3 mg/ml), THF, and methanol (=02 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
An indolocarbazole topoisomerase inhibitor shows significant antitumor properties
MDL NUMBER
MFCD01718312
INCHI
InChI=1S/C27H21Cl2N3O7/c1-38-24-13(8-33)39-27(23(35)22(24)34)32-20-10(5-3-7-12(20)29)15-17-16(25(36)31-26(17)37)14-9-4-2-6-11(28)18(9)30-19(14)21(15)32/h2-7,13,22-24,27,30,33-35H,8H2,1H3,(H,31,36,37)/t13-,22-,23-,24-,27-/m1/s1
SMILES
CO[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)n2c3c(cccc3Cl)c4c2c5c(c6cccc(c6[nH]5)Cl)c7c4C(=O)NC7=O)CO
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