Reversine
SKU
R-2034
- CAS:656820-32-5
- Formula:C12H27N7O
- MW:393.49
- Appearance:Off-White Solid
- Purity:98% by TLC

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A cell-permeable, potent, and selective human A adenosine receptor antagonist (K= 0.66M) and an aurora kinase inhibitor (IC of 30-550 nM for blast colony formation assay). Induces dedifferentiation in murine C2C12 myoblasts. Thye cells were also shown to regain multipluripotency following removal of the compound.
More Information
Alternate Name/Synonyms
2-(4-Morpholinoanilino)-6-cyclohexylaminopurine
SKU
R-2034
CAS #
656820-32-5
Chemical Name
2-(4-Morpholinoanilino)-6-cyclohexylaminopurine
Chemical Formula
C12H27N7O
Molecular Weight
393.49
Appearance
Off-White Solid
Purity
98% by TLC
Solubility
Soluble in DMSO (~7-10 mg/ml)
Storage Temp
Store at -20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells
MDL NUMBER
MFCD09953189
CHEMACX
X1494446-8
INCHI
InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)
SMILES
c1cc(ccc1Nc2nc3c(c(n2)NC4CCCCC4)nc[nH]3)N5CCOCC5
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
Handling | Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure. |
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UN #'S | Not Applicable |
Packing Group | Not Applicable |