SDS
CofA
A DNA methyltransferase (DNMT) inhibitor. RG-108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In combination with BIX 01294 (Cat. No. 1678-5), RG-108 enhances programming.
More Information
Alternate Name/Synonyms
N-Phthalyl-L-tryptophan
SKU
R-2030
CAS #
48208-26-0
Chemical Name
(2S)-2-(1,3-DIOXOISOINDOL-2-YL)-3-(1H-INDOL-3-YL)PROPANOIC ACID
Chemical Formula
C19H14N2O4
Molecular Weight
334.33
Appearance
Beige to yellow Solid
Purity
98% by HPLC
Solubility
Soluble in DMSO (10 mg/ml)
Storage Temp
Store at -20°C. Protect from air and light
THERAPEUTIC AREA
Oncological Disorders
USE
Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells
MDL NUMBER
MFCD08705332
CHEMACX
X1544237-6
INCHI
InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)/t16-/m0/s1
SMILES
c1ccc2c(c1)c(c[nH]2)C[C@@H](C(=O)O)N3C(=O)c4ccccc4C3=O
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
| Handling | Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure. |
|---|---|
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |
