Ridaforolimus

SKU
R-2597
  • CAS:572924-54-0
  • Formula:C53H84NO14P
  • MW:990.2
  • Appearance:White solid
  • Purity:>95% by HPLC
Product Name Qty
Ridaforolimus
1 mg
$180.61
Ridaforolimus
5 mg
$631.58

*Please inquire the availability for this product. Ridaforolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a dimethylphosphinate moiety. Like all tacrolimus analogues, ridaforolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing its interaction with target proteins. Ridaforolimus is extensively cited in the literature with over 70 citations.

More Information
Alternate Name/Synonyms
AP 23573, MK 8669, 42-Dimethylphosphinate-rapamycin
SKU
R-2597
CAS #
572924-54-0
Chemical Formula
C53H84NO14P
Molecular Weight
990.2
Appearance
White solid
Purity
>95% by HPLC
THERAPEUTIC AREA
Oncological Disorders
USE
Ridaforolimus a selective FRAP (mTOR) inhibitor shows antiproliferative activity
MDL NUMBER
MFCD13184816
INCHI
InChI=1S/C53H84NO14P/c1-32-18-14-13-15-19-33(2)44(63-8)30-40-23-21-38(7)53(61,67-40)50(58)51(59)54-25-17-16-20-41(54)52(60)66-45(35(4)28-39-22-24-43(46(29-39)64-9)68-69(11,12)62)31-42(55)34(3)27-37(6)48(57)49(65-10)47(56)36(5)26-32/h13-15,18-19,27,32,34-36,38-41,43-46,48-49,57,61H,16-17,20-26,28-31H2,1-12H3/b15-13+,18-14+,33-19+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
SMILES
C[C@@H]1CCC2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OP(=O)(C)C)C)/C)O)OC)C)C)/C)OC
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