Bisindolylmaleimide IX methanesulfonate

SKU
R-2418
  • CAS:138489-18-6
  • Formula:C25H23N5O2S.CH4O3S
  • MW:553.65
  • Appearance:Red solid
  • Purity:≥98% by NMR
Product Name Qty
Bisindolylmaleimide IX methanesulfonate
1 mg
$85.43
Bisindolylmaleimide IX methanesulfonate
5 mg
$324.64
Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits protein kinase A (PKA) (IC50 = 0.9 μM) and calcium/calmodulin kinase II (IC50 = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC50 = 6.8 nM).
More Information
Alternate Name/Synonyms
BIM IX; Ro 31-8220 methanesulfonate
SKU
R-2418
CAS #
138489-18-6
Chemical Name
2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate
Chemical Formula
C25H23N5O2S.CH4O3S
Molecular Weight
553.65
Appearance
Red solid
Purity
≥98% by NMR
Solubility
DMSO (~ 100 mg/ml) or water (~ 5 mg/ml)
Storage Temp
-20°C
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