Rocaglamide

SKU
R-2420
  • CAS:84573-16-0
  • Formula:C29H31NO7
  • MW:505.56
  • Appearance:White to off-white Solid
  • Purity:98% by HPLC
Product Name Qty
Rocaglamide
100 ug
$385.28
An immunosuppressant and a potent inhibitor of NF-B activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-, TNF, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-B and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.
More Information
Alternate Name/Synonyms
Rocaglamide A
SKU
R-2420
CAS #
84573-16-0
Chemical Name
(1R,2R,3S,3AR,8BS)-1,8B-DIHYDROXY-6,8-DIMETHOXY-3A-(4-METHOXYPHENYL)-N,N-DIMETHYL-3-PHENYL-2,3-DIHYDRO-1H-CYCLOPENTA[B][1]BENZOFURAN-2-CARBOXAMIDE
Chemical Formula
C29H31NO7
Molecular Weight
505.56
Appearance
White to off-white Solid
Purity
98% by HPLC
Solubility
Soluble in DMSO or EtOH
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Rocaglamide is a potent anticancer agent 
MDL NUMBER
MFCD08702699
CHEMACX
X1881329-5
INCHI
InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1
SMILES
CN(C)C(=O)[C@@H]1[C@H]([C@]2([C@@]([C@@H]1O)(c3c(cc(cc3OC)OC)O2)O)c4ccc(cc4)OC)c5ccccc5
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
E-Guides
N/A
Blog Post
N/A
Certificate of Analysis 1
Promo text for AGS discount
N/A
Handling Protect from air and light
UN #'S Not Applicable
Packing Group Not Applicable
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