Rolitetracycline

SKU
R-2603
  • CAS:751-97-3
  • Formula:C27H33N3O8
  • MW:527.6
  • Appearance:Yellow to orange solid
  • Purity:>98% by HPLC
Product Name Qty
Rolitetracycline
5 mg
$113.02
Rolitetracycline
25 mg
$396.19
*Please inquire the availability for this product. Rolitetracycline, launched in the late 1950s, was the first of the semi-synthetic tetracyclines. Rolitetracycline is formed by a Mannich condensation of formaldehyde and pyrrolidine with tetracycline. Rolitetracycline is a pro-drug of tetracycline, in which the pyrrolidine moiety improves bioavailability compared with tetracycline. Rolitetracycline has broad spectrum Gram positive activity in vivo, but pH instability limits use to parenteral administration. The intrinsic in vitro activity and SARs for this region of the tetracycline molecule have not been extensively investigated.
More Information
Alternate Name/Synonyms
Abricycline, Pyrrolidinylmethyltetracycline, SQ 15659, Transcycline, Velacycline
SKU
R-2603
CAS #
751-97-3
Chemical Formula
C27H33N3O8
Molecular Weight
527.6
Appearance
Yellow to orange solid
Purity
>98% by HPLC
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Rolitetracycline a tetracycline antibiotic has broad spectrum Gram positive activity
MDL NUMBER
MFCD00864995
INCHI
InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14-,15-,20-,26+,27-/m0/s1
SMILES
C[C@]1(c2cccc(c2C(=O)C3=C([C@]4([C@@H](C[C@@H]31)[C@@H](C(=C(C4=O)C(=O)NCN5CCCC5)O)N(C)C)O)O)O)O
To Top