Romidepsin, HDAC inhibitor
- Appearance:Colorless waxy solid
- Purity:98% by HPLC NMR (Conforms)
Romidepsin (2-128517-07-7) is a potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively. Induces apoptosis in a variety of cell lines and displays antitumor activity in mouse models. Romidepsin was recently approved for clinical use in T-cell lymphoma.