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Rottlerin

SKU
R-1120
  • CAS:82-08-6
  • Formula:C30H28O8
  • MW:516.6 Da
  • Appearance:Brown crystalline powder
  • Purity:≥98%

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SDS
CofA
Product Name Qty
Rottlerin
10 mg
$62.65
Rottlerin
25 mg
$136.69
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Rottlerin is a principal phenolic compound of the Kamala plant Mallotus philippinensis. It is a widely-used selective inhibitor of PKCδ (protein kinase Cδ). It also inhibits PKCα, PKCβ, PKCγ, PKCε, PKCη, PKCζ and eEF2K (CaMK III).

In HT1080 human fibrosarcoma cells, rottlerin induces apoptosis and autophagy via a PKCδ-independent pathway. When tested on HERG (human Ether-á-go-go) channels, rottlerin increased both step and tail HERG current by leftward shifting the voltage and dependence of HERG activation and slowing channel deactivation.

Rottlerin is an inhibitor of Chk2, MAPKAPK-2, Pim-3, PKCλ, PKCθ, Plk, PRAK, SRPK1 and an activator of AMPK and HERG. There have been a number of studies published with evidence against the role of Rotterlin as a specific PKCδ inhibitor.

More Information
Alternate Name/Synonyms
Mallotoxin; Kamalin
SKU
R-1120
CAS #
82-08-6
Chemical Name
(E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one
Chemical Formula
C30H28O8
Molecular Weight
516.6 Da
Appearance
Brown crystalline powder
Purity
≥98%
Solubility
DMSO (50 mg/mL)
Storage Temp
20°C, dissicated
THERAPEUTIC AREA
Cardiological Disorders
USE
Rottlerin (mallotoxin) has been shown to be a potent activator of the large conductance voltage and Ca2 activated K+ channel and to potently leftward shift the conductance-voltage relationship of the channel. Mallatoxin tested on hERG channels increased both step and tail hERG current by leftward shifting the voltage dependence of hERG activation and slowing channel deactivation. These actions distinguish Mallatoxin as a novel naturally occurring hERG channel activator.
MDL NUMBER
MFCD00017361
CHEMACX
X1286336-8
INCHI
InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
SMILES
Cc1c(c(c(c(c1O)C(=O)C)O)Cc2c(c3c(c(c2O)C(=O)/C=C/c4ccccc4)OC(C=C3)(C)C)O)O
Peptide sequence
Not Applicable
RTECS
AM6913800
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product
Certificate of Analysis 1
R-1120, F1224D.pdf
Certificate of Analysis 2
R-1120, F1224C.pdf
Certificate of Analysis 3
R-1120, F1224B.pdf
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product
UN #'S Not Applicable
Packing Group Not Applicable
Citations Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK)
Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice
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