- Appearance:Yellow solid with a green cast
- Purity:≥98% (HPLC)
Rubiginone D2, isolated from the strain of Streptomyces sp. (strain Gö N1/5) exhibit potential vincristine-induced cytotoxicity against multi-drug-resistant tumor cells.
Rubiginones feature the typical benz[a]anthraquinone structure of the angucyclinone antibiotics, a growing class of secondary metabolites with remarkable biological properties.
New biologically active rubiginones from Streptomyces sp., Puder C, et al, J Antibiot 53(4):329-36 (2000)
Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity., Oka M, et al, J Antibiot 43(8):967-76 (1990)