Rucaparib Phosphate

SKU
R-3000
  • CAS:459868-92-9
  • Formula:C19H18FN3O • H3PO4
  • MW:421.4 Da
  • Appearance:Yellow powder
  • Purity:>98% (HPLC)
Product Name Qty
Rucaparib Phosphate
5 mg
$81.59
Rucaparib Phosphate
25 mg
$295.79

Description

Rucaparib is a tricyclic indole PARP1, 2 and 3 inhibitor that suppresses DNA repair and thereby causes eventual cell death. Owing to its ability to prevent ordinary DNA repair, it can be used to great effect in conjunction with agents that actively induce DNA damage in the treatment of certain cancers. Specifically, it is used to treat advanced stages of ovarian cancer associated with mutations of the BRCA1 and 2 genes. Rucaparib has also been studied to a limited extent as an alternative to standard treatments for advanced cases of prostate cancer. Rucaparib phosphate is a specific phosphate salt form of the compound.

 

More Information
Alternate Name/Synonyms
Rucaparib; AG-14699; PF01367338
SKU
R-3000
CAS #
459868-92-9
Chemical Name
8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one, phosphate
Chemical Formula
C19H18FN3O • H3PO4
Molecular Weight
421.4 Da
Appearance
Yellow powder
Purity
>98% (HPLC)
Solubility
DMSO (25mg/mL)
Storage Temp
Store desiccated -20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Rucaparib Phosphate is a potent and oral PARP inhibitor. It targets NF-κB activated by DNA damage and overcomes toxicity observed with classical NF-κB inhibitors without compromising other vital inflammatory functions. It has potential in intra-cranial malignancy therapy since it is detected in the brain tissue.
INCHI
FCCGJTKEKXUBFZ-UHFFFAOYSA-N
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
GHS PICTOGRAMS
HandlingUse only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
We found other products you might like!
To Top