RVX-208, BET bromodomain inhibitor
- Appearance:White solid
- Purity:98% by TLC NMR (Conforms)
RVX-208 (1044870-39-4) is a potent BET bromodomain antagonist with IC50 of 0.510 μM for BD2, with approximately 170-fold selectivity over BD1. RVX-208 increases apolipoprotein A-1 and HDL cholesterol in vitro and in vivo. Reduces atherosclerosis.
98% by TLC NMR (Conforms)
Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.