(S)-(+)-Rolipram

SKU
R-1203
  • CAS:85416-73-5
  • Formula:C16H21NO3
  • MW:275.35
  • Appearance:Solid
  • Purity:>99%
Product Name Qty
(S)-(+)-Rolipram
inquire
$0.00

 Less active enantiomer of (RS)-Rolipram. Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It was previously used as an antideppresant but was discontinued because of its serious side effects. Rolipram has shown to boost the levels of NMNAT2 (Nicotinamide mononeucleotide adenylyl transferase 2), an enzyme that blocks the processes associated with dementia - a form of Alzheimers. In other studies it has shown to breakdown misfolded tau proteins.

*Also See R1012 (R,S) Rolipram or R-1013 (R) Rolipram.

More Information
SKU
R-1203
CAS #
85416-73-5
Chemical Name
(S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Chemical Formula
C16H21NO3
Molecular Weight
275.35
Appearance
Solid
Purity
>99%
Solubility
Soluble to 100mM in DMSO
Melting Point
128-129 °C
Storage Temp
Store at + 4 °C under desiccating conditions.
USE
Used in Neurodegenrative Disease research as a PDE4 inhibitor.
MDL NUMBER
MFCD03093861
CHEMACX
X1461533-5
INCHI
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
SMILES
COc1ccc(cc1OC2CCCC2)[C@@H]3CC(=O)NC3
Promo text for AGS discount
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