Salinomycin

SKU
S-2747
  • CAS:53003-10-4
  • Formula:C42H70O11
  • MW:751.0 Da
  • Appearance:Lyophilized light-yellow powder
  • Purity:99%

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Product Name Qty
Salinomycin
5 mg
$79.99
Salinomycin
25 mg
$284.99

Description & Applications

Salinomycin is an ionophore isolated from Streptomyces sp. that demonstrates an affinity for sodium and potassium ions. It is most commonly used in agriculture, where it is administered both as an anticoccidial drug for poultry and as a promoter of growth in ruminant animals. It is, however, known to have toxic effects when administered to some animals, particularly horses.

Beyond its agricultural applications, salinomycin has undergone considerable research in recent years as a novel anticancer drug. Of particular interest is the demonstrated ability of salinomycin to overcome cancers that exhibit multidrug resistance. Salinomycin has also been shown to target cancer stem cells. Research into the mechanism by which salinomycin exerts its anticancer effects is ongoing, but it is currently believed to be a result of the drug's ability to interfere with a group of signaling pathways involved in cancer progression, including Notch and Hedgehog.

Specifications

• Polyether ionophore
• Broad spectrum Gram-positive and anti-coccidial activity
• High affinity for monovalent cations

 

More Information
Alternate Name/Synonyms
Antibiotic 61477, Coxistac, Bio-Cox, Salocin
SKU
S-2747
CAS #
53003-10-4
Chemical Name
(2R)-2-[(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butan
Chemical Formula
C42H70O11
Molecular Weight
751.0 Da
Appearance
Lyophilized light-yellow powder
Purity
99%
Solubility
DMSO: clear colorless solution at 10 mg/mL
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious diseases
USE
Salinomycin is a polyether ionophore with broad spectrum Gram-positive and anti-coccidial activity.
MDL NUMBER
MFCD00865281
INCHI
InChI=1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1
SMILES
CC[C@H]([C@H]1CC[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C(=O)O
Handling
Danger! Fatal if swallowed.
GHS PICTOGRAMS
Handling Danger! Fatal if swallowed.
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