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SANT-1

SKU
S-2162
  • CAS:304909-07-7
  • Formula:C23H27N5
  • MW:373.49
  • Appearance:Pale yellow Solid
  • Purity:98% by HPLC
Product Name Qty
SANT-1
1 mg
$88.30
SANT-1
5 mg
$281.46
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Cell-permeable. A potent inhibitior of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an ICof 20 nM in Shh-LIGHT2 cells. SANT-1 inhibits both wild type and oncogenic Smo with equal potency.
More Information
Alternate Name/Synonyms
N-[3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
SKU
S-2162
CAS #
304909-07-7
Chemical Name
N-[3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Chemical Formula
C23H27N5
Molecular Weight
373.49
Appearance
Pale yellow Solid
Purity
98% by HPLC
Solubility
DMSO (~50 mM) or EtOH (~25 mM)
Storage Temp
Store at -20°C. Protect from air and light.
THERAPEUTIC AREA
Oncological Disorders
USE
A Smo inhibitor and Sonic Hedgehog signaling pathway antagonist use in cancer
MDL NUMBER
MFCD01827306
CHEMACX
X1438040-4
INCHI
InChI=1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
SMILES
Cc1c(c(n(n1)c2ccccc2)C)/C=N/N3CCN(CC3)Cc4ccccc4
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Do not take internally. Wear gloves and mask wehn handling the product.Avoid contact by all modes of exposure.
Handling Do not take internally. Wear gloves and mask wehn handling the product.Avoid contact by all modes of exposure.
UN #'S Not Applicable
Packing Group Not Applicable
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