SDS
CofA
Cell-permeable. A potent inhibitior of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an ICof 20 nM in Shh-LIGHT2 cells. SANT-1 inhibits both wild type and oncogenic Smo with equal potency.
More Information
Alternate Name/Synonyms
N-[3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
SKU
S-2162
CAS #
304909-07-7
Chemical Name
N-[3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Chemical Formula
C23H27N5
Molecular Weight
373.49
Appearance
Pale yellow Solid
Purity
98% by HPLC
Solubility
DMSO (~50 mM) or EtOH (~25 mM)
Storage Temp
Store at -20°C. Protect from air and light.
THERAPEUTIC AREA
Oncological Disorders
USE
A Smo inhibitor and Sonic Hedgehog signaling pathway antagonist use in cancer
MDL NUMBER
MFCD01827306
CHEMACX
X1438040-4
INCHI
InChI=1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
SMILES
Cc1c(c(n(n1)c2ccccc2)C)/C=N/N3CCN(CC3)Cc4ccccc4
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Do not take internally. Wear gloves and mask wehn handling the product.Avoid contact by all modes of exposure.
| Handling | Do not take internally. Wear gloves and mask wehn handling the product.Avoid contact by all modes of exposure. |
|---|---|
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |
