SB 203580

Product Name	Qty
SB-203580 1 mg $93.82
SB-203580 5 mg $364.24

Details

SB-203580 is a pyridinyl imidazole which acts as a specific inhibitor of p38 MAP Kinase. SB-203580 does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.

Specifications

More Information

Alternate Name/Synonyms

4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

SKU

S-1014

CAS #

152121-47-6

Chemical Name

4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

Chemical Formula

C₂₁H₁₆N₃FOS

Molecular Weight

377.4

Appearance

White to Off-White Solid

Purity

≥98%

Solubility

Soluble in DMSO (50mg/ml) or methanol.

Storage Temp

-20°C, Warning! Irritant. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light.

Certificate of Analysis 1

S-1014, H1146.pdf

Certificate of Analysis 2

S-1014, F1116A.pdf

Certificate of Analysis 3

S-1014, F1116.pdf

Reviews

Safety

Citations

Citations	Vibrational spectroscopy in sensing radiobiological effects: analyses of targeted and non-targeted effects in human keratinocytes
	Src-family kinase signaling modulates the adhesion of Plasmodium falciparum on human microvascular endothelium under flow
	Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death
	Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling
	Semaphorin3A accelerates neuronal polarity in vitro and in its absence the orientation of DRG neuronal polarity in vivo is distorted
	Significance of α-SMA in myofibroblasts emerging in renal tubulointerstitial fibrosis
	Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor
	Extracellular signal-regulated kinase mediates granulocyte-macrophage colony-stimulating factor messenger RNA stabilization in tumor necrosis factor-alpha plus fibronectin-activated peripheral blood eosinophils
	Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha
	Mechanical stretch induces podocyte hypertrophy in vitro
	Cell density mediated pericellular hypoxia leads to induction of HIF-1alpha via nitric oxide and Ras/MAP kinase mediated signaling pathways
	Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc
	Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis
	Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles
	Role of p38 mitogen-activated protein kinase in chemokine-induced emigration and chemotaxis in vivo
	COMP-Angiopoietin-1 accelerates muscle regeneration through N-cadherin activation
	A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway
	Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition
	Involvement of AMP-activated protein kinase and p38 mitogen-activated protein kinase in 8-Cl-cAMP-induced growth inhibition
	Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells
	Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2
	Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways
	The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner
	Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration
	IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression through JAK1 and STAT6
	Role of CREB in modulation of TNFalpha and IL-10 expression in LPS-stimulated RAW264.7 macrophages
	Crocin suppresses LPS-stimulated expression of inducible nitric oxide synthase by upregulation of heme oxygenase-1 via calcium/calmodulin-dependent protein kinase 4
	Beta-carboline alkaloids harmaline and harmalol induce melanogenesis through p38 mitogen-activated protein kinase in B16F10 mouse melanoma cells
	Role of integrins and focal adhesion kinase in the orientation of dermal fibroblasts exposed to cyclic strain
	Cell survival signalling in heart derived myofibroblasts induced by preconditioning and bradykinin: The role of p38 MAP kinase
	p38 mitogen-activated protein kinase and calcium channels mediate signaling in depolarization-induced activation of peroxisome proliferator-activated receptor gamma coactivator-1alpha in neurons
	SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment
	Acanthopanax senticosus exerts neuroprotective effects through HO-1 signaling in hippocampal and microglial cells
	Dendrobium moniliforme Stem Extract Inhibits Lipoteichoic Acid-Induced Inflammatory Responses by Upregulation of Heme Oxygenase-1
	Hinokitiol increases the angiogenic potential of dental pulp cells through ERK and p38MAPK activation and hypoxia-inducible factor-1α (HIF-1α) upregulation
	Autocrine extracellular signal-regulated kinase activation in normal human keratinocytes is not interrupted by calcium triggering and is involved in the control of cell cycle at the early stage of calcium-induced differentiation
	COMP-Ang1 accelerates regeneration of ischemia-damaged skeletal muscle through dual regulation
	Oxaliplatin による冷感誘発末梢神経障害と Transient Receptor Potential Ankyrin 1, 電位依存性カルシウムチャネ α2δ-1 に関する研究
	Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling
	C-reactive protein induces p53-mediated cell cycle arrest in H9c2 cardiac myocytes
	Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration
	Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt