SB 203580

  • CAS:152121-47-6
  • Formula:C21H16N3FOS
  • MW:377.4
  • Appearance:White to Off-White Solid
  • Purity:≥98%
Product Name Qty
1 mg
5 mg

SB-203580 is a pyridinyl imidazole which acts as a specific inhibitor of p38 MAP Kinase. SB-203580 does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.

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Alternate Name/Synonyms
Chemical Name
Chemical Formula
Molecular Weight
White to Off-White Solid
Soluble in DMSO (50mg/ml) or methanol.
Storage Temp
-20°C, Warning! Irritant. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
CitationsVibrational spectroscopy in sensing radiobiological effects: analyses of targeted and non-targeted effects in human keratinocytes
Src-family kinase signaling modulates the adhesion of Plasmodium falciparum on human microvascular endothelium under flow
Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death
Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling
Semaphorin3A accelerates neuronal polarity in vitro and in its absence the orientation of DRG neuronal polarity in vivo is distorted
Significance of α-SMA in myofibroblasts emerging in renal tubulointerstitial fibrosis
Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor
Extracellular signal-regulated kinase mediates granulocyte-macrophage colony-stimulating factor messenger RNA stabilization in tumor necrosis factor-alpha plus fibronectin-activated peripheral blood eosinophils
Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha
Mechanical stretch induces podocyte hypertrophy in vitro
Cell density mediated pericellular hypoxia leads to induction of HIF-1alpha via nitric oxide and Ras/MAP kinase mediated signaling pathways
Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc
Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis
Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles
Role of p38 mitogen-activated protein kinase in chemokine-induced emigration and chemotaxis in vivo
COMP-Angiopoietin-1 accelerates muscle regeneration through N-cadherin activation
A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway
Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition
Involvement of AMP-activated protein kinase and p38 mitogen-activated protein kinase in 8-Cl-cAMP-induced growth inhibition
Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells
Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2
Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways
The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner
Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration
IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression through JAK1 and STAT6
Role of CREB in modulation of TNFalpha and IL-10 expression in LPS-stimulated RAW264.7 macrophages
Crocin suppresses LPS-stimulated expression of inducible nitric oxide synthase by upregulation of heme oxygenase-1 via calcium/calmodulin-dependent protein kinase 4
Beta-carboline alkaloids harmaline and harmalol induce melanogenesis through p38 mitogen-activated protein kinase in B16F10 mouse melanoma cells
Role of integrins and focal adhesion kinase in the orientation of dermal fibroblasts exposed to cyclic strain
Cell survival signalling in heart derived myofibroblasts induced by preconditioning and bradykinin: The role of p38 MAP kinase
p38 mitogen-activated protein kinase and calcium channels mediate signaling in depolarization-induced activation of peroxisome proliferator-activated receptor gamma coactivator-1alpha in neurons
SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment
Acanthopanax senticosus exerts neuroprotective effects through HO-1 signaling in hippocampal and microglial cells
Dendrobium moniliforme Stem Extract Inhibits Lipoteichoic Acid-Induced Inflammatory Responses by Upregulation of Heme Oxygenase-1
Hinokitiol increases the angiogenic potential of dental pulp cells through ERK and p38MAPK activation and hypoxia-inducible factor-1α (HIF-1α) upregulation
Autocrine extracellular signal-regulated kinase activation in normal human keratinocytes is not interrupted by calcium triggering and is involved in the control of cell cycle at the early stage of calcium-induced differentiation
COMP-Ang1 accelerates regeneration of ischemia-damaged skeletal muscle through dual regulation
Oxaliplatin による冷感誘発末梢神経障害と Transient Receptor Potential Ankyrin 1, 電位依存性カル シウムチャネ α2δ-1 に関する研究
Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling
C-reactive protein induces p53-mediated cell cycle arrest in H9c2 cardiac myocytes
Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration
Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt
The Pseudomonas aeruginosa HSP90-like protein HtpG regulates IL-8 expression through NF-κB/p38 MAPK and CYLD signaling triggered by TLR4 and CD91
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