SB-216763

SKU
S-2426
  • CAS:280744-09-4
  • Formula:C19H12Cl2N2O2
  • MW:371.22
  • Appearance:Orange Solid
  • Purity:98% by HPLC
Product Name Qty
SB-216763
1 mg
$85.43
SB-216763
5 mg
$336.03

A potent, cell-permeable and ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) (K= 9 nM for GSK-3). Has little activity against 24 other protein kinases (IC 10M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

More Information
Alternate Name/Synonyms
3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
SKU
S-2426
CAS #
280744-09-4
Chemical Name
3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Chemical Formula
C19H12Cl2N2O2
Molecular Weight
371.22
Appearance
Orange Solid
Purity
98% by HPLC
Solubility
DMSO (50 mM)
Storage Temp
-20°C
THERAPEUTIC AREA
Neurological Disorders
USE
SB 216763 is a cell-permeable, potent, selective and ATP-competitive inhibitor of GSK-3 used in Alzheimer's disease,non-insulin dependent diabetes mellitus and neurodegenerative disease
MDL NUMBER
MFCD09753369
CHEMACX
X1395407-3
INCHI
InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
SMILES
Cn1cc(c2c1cccc2)C3=C(C(=O)NC3=O)c4ccc(cc4Cl)Cl
RTECS
UX9565000
Handling
Protect from air and light
Handling Protect from air and light
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