SB-431542

SKU
S-2122
  • CAS:301836-41-9
  • Formula:C22H16N4O3
  • MW:384.39
  • Appearance:Crystalline Solid
  • Purity:98%
Product Name Qty
SB-431542
1 mg
$108.21
A potent and selective inhibitor of the TGF- 1 receptor ALK5 (IC= 94 nM). It inhibits ALK4 only at higher concentrations (IC= 140 nM). Suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes their differentiation through its effect on Smad signaling pathway.
More Information
Alternate Name/Synonyms
4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
SKU
S-2122
CAS #
301836-41-9
Chemical Name
4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Chemical Formula
C22H16N4O3
Molecular Weight
384.39
Appearance
Crystalline Solid
Purity
98%
Solubility
DMSO (20 mg/ml) or Ethanol (2 mg/ml)
Melting Point
315.72 °C
Storage Temp
Store at -20°C. Protect from air and light
THERAPEUTIC AREA
Oncological Disorders
USE
A specific and selective inhibitor of TGF-ß type I ALK receptors and Smad3.It also suppressed the TGF-beta-induced proliferation of osteosarcoma
MDL NUMBER
MFCD05865244
CHEMACX
X1430393-8
INCHI
InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
SMILES
c1ccnc(c1)c2c(nc([nH]2)c3ccc(cc3)C(=O)N)c4ccc5c(c4)OCO5
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
Certificate of Analysis 1
Handling Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
UN #'S Not Applicable
Packing Group Not Applicable
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