Siccanin

SKU
S-2767
  • CAS:22733-60-4
  • Formula:C22H30O3
  • MW:342.5
  • Appearance:White solid
  • Purity:>98% by HPLC
Product Name Qty
Siccanin
1 mg
$341.72
Siccanin
5 mg
$1,196.02
*Please inquire the availability for this product. Siccanin is an unusual fused phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.
More Information
Alternate Name/Synonyms
CS 280, SI 23548
SKU
S-2767
CAS #
22733-60-4
Chemical Formula
C22H30O3
Molecular Weight
342.5
Appearance
White solid
Purity
>98% by HPLC
Solubility
Soluble in ethanol, methanol, DMSO, DMF, and water (poorly)
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Siccanin is an potent antifungal agent
MDL NUMBER
MFCD00242750
INCHI
InChI=1S/C22H30O3/c1-13-10-14(23)17-15(11-13)25-21(4)9-6-16-20(2,3)7-5-8-22(16)12-24-18(17)19(21)22/h10-11,16,18-19,23H,5-9,12H2,1-4H3/t16?,18?,19-,21?,22?/m0/s1
SMILES
Cc1cc(c2c(c1)OC3(CCC4C(CCCC45[C@H]3C2OC5)(C)C)C)O
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