Simvastatin

SKU
S-2004
  • CAS:79902-63-9
  • Formula:C25H38O5
  • MW:418.6
  • Appearance:White to Off-White Solid
  • Purity:98%
Product Name Qty
Simvastatin
50 mg
$131.00
Simvastatin
250 mg
$523.97

HMG-CoA reductase inhibitor. Simvastatin inhibits the biosynthesis of isoprenoids and prevents small G protein activation. Displays lipid lowering and antihypertensive effects. Displays antiinflammatory, immunomodulatory effects as well as protective effects in experimental traumatic brain injury. Activates Rac1-dependent signaling pathway.Simvastatin Induces Heme Oxygenase-1: A Novel Mechanism of Vessel Protection.

More Information
Alternate Name/Synonyms
Synvinolin, MK-733
SKU
S-2004
CAS #
79902-63-9
Chemical Name
(1S,3R,7S,8S,8AR)-8-(2-[(2R,4R)-4-HYDROXY-6-OXOTETRAHYDRO-2H-PYRAN-2-YL]ETHYL)-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL 2,2-DIMETHYLBUTANOATE
Chemical Formula
C25H38O5
Molecular Weight
418.6
Appearance
White to Off-White Solid
Purity
98%
Solubility
Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml); insoluble in water.
Melting Point
127-132 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Vascular Disorders, Metabolic Disorders
USE
Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor used in the treatment of hypercholesterolemia
MDL NUMBER
MFCD00072007
CHEMACX
X1000597-9
INCHI
InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
SMILES
CC[C@@](C(=O)O[C@@H]1[C@H]2C(=C[C@@H](C1)C)C=C[C@@H]([C@@H]2CC[C@H]3OC(=O)C[C@@H](C3)O)C)(C)C
Peptide sequence
Not Applicable
RTECS
EK7798000
UN #'S
UN 3077
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed VialStable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling Store in Tightly Sealed VialStable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
UN #'S UN 3077
Packing Group III
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