Siomycin A

SKU
S-2771
  • CAS:12656-09-6
  • Formula:C71H81N19O18S5
  • MW:1648.9
  • Appearance:White solid
  • Purity:>95% by HPLC
Product Name Qty
Siomycin A
0.5 mg
$378.26
Siomycin A
2.5 mg
$1,298.50
*Please inquire the availability for this product. Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Siomycin is a potent inhibitor of the oncogenic transcription factor, FoxM1. The reduced transcription activity is reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes, Cdc25B, survivin and CENPB. In vitro, siomycin inhibits FoxM1-induced cell growth on soft agar and selectively kills transformed but not normal cells.
More Information
Alternate Name/Synonyms
Mutabilycin, Sporangiomycin, 6741-21, Mutabillicin
SKU
S-2771
CAS #
12656-09-6
Chemical Formula
C71H81N19O18S5
Molecular Weight
1648.9
Appearance
White solid
Purity
>95% by HPLC
Solubility
DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity
MDL NUMBER
MFCD01750111
INCHI
InChI=1S/C71H81N19O18S5/c1-14-37-64-83-44(22-109-64)61(103)89-52(70(13,107)34(12)93)67-85-43(23-112-67)59(101)88-48-33(11)108-68(106)40-19-36(31(9)91)35-15-16-38(50(94)49(35)79-40)78-46(25(2)3)62(104)77-29(7)56(98)74-27(5)55(97)75-30(8)57(99)90-71(69-86-45(24-113-69)60(102)87-47(32(10)92)63(105)81-37)18-17-39(80-51(71)41-20-111-66(48)82-41)65-84-42(21-110-65)58(100)76-28(6)54(96)73-26(4)53(72)95/h14-16,19-21,23-25,30-34,38,44,46-48,50-52,78,91-94,107H,4-7,17-18,22H2,1-3,8-13H3,(H2,72,95)(H,73,96)(H,74,98)(H,75,97)(H,76,100)(H,77,104)(H,81,105)(H,87,102)(H,88,101)(H,89,103)(H,90,99)/b37-14-/t30-,31-,32+,33+,34+,38+,44+,46-,47-,48-,50-,51+,52+,70+,71+/m0/s1
SMILES
C/C=C\1/C2=N[C@H](CS2)C(=O)N[C@H](c3nc(cs3)C(=O)N[C@@H]4c5nc(cs5)[C@@H]6[C@](CCC(=N6)c7nc(cs7)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)(c8nc(cs8)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)[C@@H](NC(=O)C(=C)NC(=O)C(=C)NC(=O)[C@@H](N[C@@H]9C=Cc1c(cc(nc1[C@H]9O)C(=O)O[C@@H]4C)[C@H](C)O)C(C)C)C)[C@@](C)([C@@H](C)O)O
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