SIRT2 Inhibitor, AGK2

SKU
S-2434
  • CAS:304896-28-4
  • Formula:C23H13Cl2N3O2
  • MW:434.27
  • Appearance:Yellow Solid
  • Purity:95% by HPLC
Product Name Qty
SIRT2 Inhibitor, AGK2
10 mg
$165.17
A potent inhibitor of sirtuin 2 (SIRT2) (IC= 3.5 M). AGK2 is 15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued synuclein toxicity and modified inclusion morphology in a cellular model of Parkinsons disease.
More Information
Alternate Name/Synonyms
AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
SKU
S-2434
CAS #
304896-28-4
Chemical Name
AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
Chemical Formula
C23H13Cl2N3O2
Molecular Weight
434.27
Appearance
Yellow Solid
Purity
95% by HPLC
Solubility
Soluble in DMSO
Storage Temp
+4°C
THERAPEUTIC AREA
Neurological Disorders
USE
A reversible inhibitor of SIRT2 activity,a histone deacetylase enzyme
MDL NUMBER
MFCD01909444
CHEMACX
X1621483-2
INCHI
InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
SMILES
c1cc2c(cccn2)c(c1)NC(=O)/C(=C/c3ccc(o3)c4cc(ccc4Cl)Cl)/C#N
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
Handling Protect from air and light
UN #'S Not Applicable
Packing Group Not Applicable
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