SMER28
SKU
S-2436
- CAS:307538-42-7
- Formula:C11H10BrN3
- MW:264.12
- Appearance:Off-White Solid
- Purity:98% by TLC
SDS
CofA
Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington's Disease (HD). Maybe a useful lead compound for the development of new therapeutics for neurodegenerative diseases. Induces the release of articular cartilage vesicles from healthy articular chondrocytes in a dose- and time-dependent manner. Promotes reprogramming of fibroblasts to neural stem-like cells. Cell permeable.
More Information
Alternate Name/Synonyms
Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline
SKU
S-2436
CAS #
307538-42-7
Chemical Name
Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline
Chemical Formula
C11H10BrN3
Molecular Weight
264.12
Appearance
Off-White Solid
Purity
98% by TLC
Solubility
DMSO (~8 mg/ml) or EtOH (~ 2 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Neurological Disorders
USE
SMER28 is a small molecule modulator of mammalian autophagy for the treatment of Alzheimer's disease & Huntingtons Disease (HD)
MDL NUMBER
MFCD02166825
CHEMACX
X1621469-2
INCHI
InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
SMILES
C=CCNc1c2cc(ccc2ncn1)Br
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
| GHS PICTOGRAMS |
|
|---|---|
| Handling | Protect from air and light |
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |