Splitomicin

SKU
S-2441
  • CAS:5690-03-9
  • Formula:C13H10O2
  • MW:198.2
  • Appearance:White to off-white Solid
  • Purity:98%
Product Name Qty
Splitomicin
5 mg
$139.59
Sirt1 inhibitor.Potent inhibitor of yeast NAD-dependent histone deacetylase Sir2p (IC= 60 M). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
More Information
Alternate Name/Synonyms
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
SKU
S-2441
CAS #
5690-03-9
Chemical Name
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Chemical Formula
C13H10O2
Molecular Weight
198.2
Appearance
White to off-white Solid
Purity
98%
Solubility
DMSO (100 mg/ml)
Storage Temp
+4°C
THERAPEUTIC AREA
Oncological Disorders
USE
Splitomicin was used to inhibit SIRT1 in human aortic endothelial cells1,2 and sirtuins in human breast cancer cells
MDL NUMBER
MFCD08705254
CHEMACX
X1430392-1
INCHI
InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
SMILES
c1ccc2c(c1)ccc3c2CCC(=O)O3
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and moisture
Promo text for AGS discount
N/A
Handling Protect from air and moisture
UN #'S Not Applicable
Packing Group Not Applicable
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