SR9243, LXR inverse agonist
SKU
S-3335
- CAS:1613028-81-1
- Formula:C31H32BrNO4S2
- MW:626.62
- Appearance:White solid
- Purity:>98% by HPLC NMR (Conforms)
SDS
CofA
SR9243 (1613028-81-1) is an LXR inverse agonist that significantly inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression. Induces apoptosis in a variety of cancer cell types including SW620 (IC50 = 40 nM), HT-29 (IC50 = 104 nM), DU-145 (IC50 = 15 nM), PC-3 (IC50 = 61 nM), NCI-H23 (IC50 = 72 nM), HOP-62 (IC50 = 26 nM) and MIAPACA-2 (IC50= 18 nM). SR9243 is able to promote apoptotic cancer cell death without adversely affecting non-malignant cells.
More Information
SKU
S-3335
CAS #
1613028-81-1
Chemical Name
N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3Õ-(methylsulfonyl)[1,1Õ-biphenyl]-4-yl]methyl]-benzenesulfonamide
Chemical Formula
C31H32BrNO4S2
Molecular Weight
626.62
Appearance
White solid
Purity
>98% by HPLC NMR (Conforms)
Solubility
Soluble in DMSO (greater than 25 mg/ml)
Storage Temp
-20°C (des.)
Hazard Image
Yes