Stauprimide, Streptomyces sp.

SKU
S-2092
  • CAS:154589-96-5
  • Formula:C35H28N4O5
  • MW:584.6
  • Appearance:Yellow Orange Solid
  • Purity:98% by TLC
Product Name Qty
Stauprimide, Streptomyces sp.
0.5 mg
$350.59
Stauprimide, Streptomyces sp.
2.5 mg
$1,187.81

Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as a potential antitumor agent. More recently, stauprimide has been shown to increase the efficiency of the directed differentiation of mouse and human embryonic stem cells in synergy with defined extracellular signalling cues. Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells.

More Information
Alternate Name/Synonyms
N-Benzoyl-7-oxostaurosporine
SKU
S-2092
CAS #
154589-96-5
Chemical Name
N-((5S,6R,7R,9R)-6-METHOXY-5-METHYL-14,16-DIOXO-5,6,7,8,9,14,15,16-OCTAHYDRO-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-7-YL)-N-METHYLBENZAMIDE
Chemical Formula
C35H28N4O5
Molecular Weight
584.6
Appearance
Yellow Orange Solid
Purity
98% by TLC
Solubility
Soluble in methanol, ethanol, DMF or DMSO
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression in certain cancers
MDL NUMBER
MFCD14635443
CHEMACX
X1763223-8
INCHI
InChI=1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1
SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Handling
Keep dry & frozen
Promo text for AGS discount
N/A
Handling Keep dry & frozen
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