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Staurosporine

SKU
S-1016
  • CAS:62996-74-1
  • Formula:C28H26N4O3
  • MW:466.5 Da
  • Appearance:White to yellow powder or lyophilized solid
  • Purity:≥98%
Product Name Qty
Staurosporine
1 mg
$135.50
Staurosporine
5 mg
$474.24
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Description

Staurosporine is a cell-permeable protein kinase inhibitor that acts by blocking interaction with the ATP binding site. It mainly inhibits protein kinase C (PKC) but most other kinases, including tyrosine kinases. It has some antifungal properties.

It has been reported that Staurosporine promotes apoptosis in various cell types by triggering both the morphological changes and intranucleosomal DNA fragmentation and by caspase-dependent and -independent ways. In addition, it has been reported that the kinase inhibitor is related to signaling pathway.

 

Applications

• Apoptosis inducer

• Antibiotic

• Protein kinase inhibitor

 

References

• “Induction of a Common Pathway of Apoptosis by Staurosporine”

• “Staurosporine-Induced Neuronal Apoptosis”

• “Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms”

• “Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Antibiotic 230; AM-2282
SKU
S-1016
CAS #
62996-74-1
Chemical Name
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
Chemical Formula
C28H26N4O3
Molecular Weight
466.5 Da
Appearance
White to yellow powder or lyophilized solid
Purity
≥98%
Solubility
DMSO (50 mg/mL) or ethanol (2 mg/mL, warm).
Storage Temp
4ºC
THERAPEUTIC AREA
Oncological Disorders
USE
Staurosporine is used to induce cell death in human mesenchymal stem cells and to induce cell death by PKC inhibition in hamster lung fibroblast line CCL-39. When encapsulated in liposome nanoparticle, staurosporine is shown to suppress tumors in vivo in a mouse model without the toxic side effects which have prohibited its use as an anti-cancer drug with high apoptotic activity. Staurosporine is also used to study the effect of caspase activation on human sperm quality.
MDL NUMBER
MFCD18252446
CHEMACX
X1000602-5
INCHI
InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)NC)OC
Handling
Wear personal protective equipment. Ensure adequate ventilation. Avoid contact with skin, eyes and clothing. Avoid dust formation. Do not breathe dust. Use only under a chemical fume hood.
msds 1
S-1016, Staurosporine, SDS, Diamond Format.pdf
Certificate of Analysis 1
S-1016, L1133.pdf
Certificate of Analysis 2
S-1016, E1076.pdf
GHS PICTOGRAMS
HandlingWear personal protective equipment. Ensure adequate ventilation. Avoid contact with skin, eyes and clothing. Avoid dust formation. Do not breathe dust. Use only under a chemical fume hood.
CitationsInhibition of DNA repair by a herpes simplex virus vector enhances the radiosensitivity of human glioblastoma cells
In vivo generation of post-infarct mouse cardiac muscle by cardiomyocyte progenitors produced with a reproducible laminin-promoted human stem cell differentiation system
RADIOSENSITIVITY ENHANCEMENT OF HUMAN GLIOBLASTOMA MULTIFORME BY A HERPES SIMPLEX VIRUS VECTOR
Investigations on the cellular and neuroprotective functions of Nogo-A/Reticulon 4A
A STUDY INTO THE PROSPECTS FOR MARINE BIOTECHNOLOGY DEVELOPMENT IN THE UNITED KINGDOM
Epizootic hemorrhagic disease virus induces and benefits from cell stress, autophagy, and apoptosis
Staurosporine sensitizes T lymphoma cells to glucocorticoid-induced apoptosis: role of Nur77 and Bcl-2
In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors
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