Staurosporine, Cell permeable inhibitor of protein kinases
SKU
S-1016
- CAS:62996-74-1
- Formula:C28H26N4O3
- MW:466.5 Da
- Appearance:White to yellow powder or lyophilized solid
- Purity:≥98%
SDS
CofA
A cell permeable general inhibitor of protein kinases. Inhibits CaM kinase ), myosin lightchain kinase , protein kinase A, protein kinase and protein kinase g .Inhibition of DNA Repair by a Herpes Simplex Virus Vector Enhances the Radiosensitivity of Human Glioblastoma Cells.
More Information
Alternate Name/Synonyms
Antibiotic 230; AM-2282
SKU
S-1016
CAS #
62996-74-1
Chemical Name
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
Chemical Formula
C28H26N4O3
Molecular Weight
466.5 Da
Appearance
White to yellow powder or lyophilized solid
Purity
≥98%
Solubility
DMSO (50 mg/mL) or ethanol (2 mg/mL, warm).
Melting Point
N/A
Preparation
N/A
Storage Temp
4ºC
THERAPEUTIC AREA
Oncological Disorders
USE
Staurosporine is used to induce cell death in human mesenchymal stem cells and to induce cell death by PKC inhibition in hamster lung fibroblast line CCL-39. When encapsulated in liposome nanoparticle, staurosporine is shown to suppress tumors in vivo in a mouse model without the toxic side effects which have prohibited its use as an anti-cancer drug with high apoptotic activity. Staurosporine is also used to study the effect of caspase activation on human sperm quality.
Merck Index
N/A
MDL NUMBER
MFCD18252446
CHEMACX
X1000602-5
INCHI
InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)NC)OC
Handling
Wear personal protective equipment. Ensure adequate ventilation. Avoid contact with skin, eyes and clothing. Avoid dust formation. Do not breathe dust. Use only under a chemical fume hood.
Certificate of Analysis 1
| GHS PICTOGRAMS |
|
|---|---|
| Handling | Wear personal protective equipment. Ensure adequate ventilation. Avoid contact with skin, eyes and clothing. Avoid dust formation. Do not breathe dust. Use only under a chemical fume hood. |