StemRegenin 1·HCl
SKU
S-2136
- CAS:1227633-49-9
- Formula:C₂₄H₂₃N₅OS‚·HCl
- MW:466.0
- Appearance:White solid
- Purity:≥98% by HPLC
SDS
CofA
StemRegenin 1 is a cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines. StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.
More Information
Alternate Name/Synonyms
SR1
SKU
S-2136
CAS #
1227633-49-9
Chemical Name
4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)phenol hydrochloride
Chemical Formula
C₂₄H₂₃N₅OS‚·HCl
Molecular Weight
466.0
Appearance
White solid
Purity
≥98% by HPLC
Solubility
DMSO (~ 10 mM)
Storage Temp
-20°C
Certificate of Analysis 1