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Streptozotocin

SKU
S-2044
  • CAS:18883-66-4
  • Formula:C8H15N3O7
  • MW:265.2 Da
  • Appearance:Pale yellow powder
  • Purity:≥97%
Product Name Qty
Streptozotocin
1 g
$138.77
Streptozotocin
500 mg
$90.74
Streptozotocin
5 gm
$528.40
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Description

Streptozotocin is an antibiotic and related to DNA alkylation and methylation. Streptozotocin forms methylated purines that react with DNA in vitro. The methylating agent effects not only liver and kidney DNA, but also pancreatic DNA.

The antibiotic enters cells GLUT2 glucose transport protein and causes type I diabetes in rat models by beta-cell necrosis. It has been reported that Streptozotocin degenerates in Langerhans islet beta cells and thus induces diabetes in rodents.

Streptozotocin has anticancer properties and is used for several tumors such as leukemia, medullary thyroid carcinoma, and islet cell cancer of the pancreas.

 

Applications

• Type 1 diabetes inducer in rat models

• DNA alkylation and methylation

• Anticancer drug

 

References

• “Induction of diabetes by Streptozotocin in rats”

• “Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus”

• “Alkylation of DNA in Rat Tissues following Administration of Streptozotocin”

• “Using molecular dynamics simulation to explore the binding of the three potent anticancer drugs sorafenib, streptozotocin, and sunitinib to functionalized carbon nanotubes”

• “Pancreatic Islet Cell Carcinoma”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Streptozocin; STZ; Zanosar
SKU
S-2044
CAS #
18883-66-4
Chemical Name
1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
Chemical Formula
C8H15N3O7
Molecular Weight
265.2 Da
Appearance
Pale yellow powder
Purity
≥97%
Solubility
Soluble in water, ethanol or DMSO at 50 mg/mL.
Melting Point
121 °C
Storage Temp
-20°C, Warning: Harmful!
THERAPEUTIC AREA
Endocrinological Disorders
USE
Streptozotocin (STZ) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals . STZ is a potent alkylating agent known to directly methylate DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. This antibiotic was found to be mutagenic in bacterial assays and eukaryotic cells. STZ is also carcinogenic; a single administration induces tumors in rat kidney, liver, and pancreas. Several lines of evidence indicate that free radicals are involved in the production of DNA and chromosome damage by this compound.
Merck Index
Merck Index: 13.8912
MDL NUMBER
MFCD00006607
CHEMACX
X1005022-7
INCHI
InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
SMILES
CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O
Peptide sequence
Not Applicable
RTECS
LZ5775000
UN #'S
UN 3077
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed
Certificate of Analysis 1
S-2044, H1006D.pdf
Certificate of Analysis 2
S-2044, H1006C.pdf
Certificate of Analysis 3
S-2044, H1006B.pdf
GHS PICTOGRAMS
HandlingAvoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed
UN #'SUN 3077
Packing GroupIII
CitationsEffect of cooking treatments on the phytochemical composition and antidiabetic potential of Vernonia amygdalina
Effect of boiling and roasting on the antidiabetic activity of Abelmoschus esculentus (Okra) fruits and seeds in type 2 diabetic rats
Modification by Ethanol and Taurine, Singly and in Combination, of Changes in Indices of Renal Dysfunction Caused by Diabetes in Rats
Taurine Improves the Actions of Metformin and Lovastatin on Plasma Markers of Carbohydrate and Lipid Dysfunction of Diabetic Rats
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