Streptozotocin
SKU
S-2044
- CAS:18883-66-4
- Formula:C8H15N3O7
- MW:265.2 Da
- Appearance:Pale yellow powder
- Purity:≥97%
SDS
CofA
Widely used diabetes inducer in rodents. It has been demonstrated that STZ's inhibition of Beta-cell O-GlcNAcase is the mechanism that accounts for its diabetogenic toxicity.
More Information
Alternate Name/Synonyms
Streptozocin; STZ; Zanosar
SKU
S-2044
CAS #
18883-66-4
Chemical Name
1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
Chemical Formula
C8H15N3O7
Molecular Weight
265.2 Da
Appearance
Pale yellow powder
Purity
≥97%
Solubility
Soluble in water, ethanol or DMSO at 50 mg/mL.
Melting Point
121 °C
Preparation
N/A
Storage Temp
-20°C, Warning: Harmful!
THERAPEUTIC AREA
Endocrinological Disorders
USE
Streptozotocin (STZ) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals . STZ is a potent alkylating agent known to directly methylate DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. This antibiotic was found to be mutagenic in bacterial assays and eukaryotic cells. STZ is also carcinogenic; a single administration induces tumors in rat kidney, liver, and pancreas. Several lines of evidence indicate that free radicals are involved in the production of DNA and chromosome damage by this compound.
Merck Index
Merck Index: 13.8912
MDL NUMBER
MFCD00006607
CHEMACX
X1005022-7
INCHI
InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
SMILES
CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O
Peptide sequence
Not Applicable
RTECS
LZ5775000
UN #'S
UN 3077
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
| GHS PICTOGRAMS |
|
|---|---|
| Handling | Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed |
| UN #'S | UN 3077 |
| Packing Group | III |