- MW:265.2 Da
- Appearance:Pale yellow powder
Widely used diabetes inducer in rodents. It has been demonstrated that STZ's inhibition of Beta-cell O-GlcNAcase is the mechanism that accounts for its diabetogenic toxicity.
Streptozocin; STZ; Zanosar
Pale yellow powder
Soluble in water, ethanol or DMSO at 50 mg/mL.
-20°C, Warning: Harmful!
Streptozotocin (STZ) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals . STZ is a potent alkylating agent known to directly methylate DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. This antibiotic was found to be mutagenic in bacterial assays and eukaryotic cells. STZ is also carcinogenic; a single administration induces tumors in rat kidney, liver, and pancreas. Several lines of evidence indicate that free radicals are involved in the production of DNA and chromosome damage by this compound.
Merck Index: 13.8912
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|Handling||Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed|
|UN #'S||UN 3077|